Principal Scientist, Preclinical Pharmacology Job at PepGen, Boston, MA

RTdlWENnV0NKbTBUekdmMnlZaS9mM1JnQ0E9PQ==
  • PepGen
  • Boston, MA

Job Description

Principal Scientist, Preclinical Pharmacology


Position Summary
PepGen is seeking a highly motivated and innovative Principal Scientist to join the Preclinical Research and Development group in Boston, Massachusetts. We are looking for a senior scientist who brings enthusiasm, curiosity, scientific rigor, and a desire to transform the future of neuromuscular and neurodegenerative diseases. The successful candidate will be primarily responsible for the key aspects of the research and development, including pharmacology, of PepGen’s Enhance Delivery Oligonucleotide (EDO) programs and future pipeline product candidates as well as interfacing with PepGen’s external contract research organization (CRO) partners. Further, the successful candidate must be able to effectively multitask, manage scientists, have strong documentation skills, and should be comfortable working in multidisciplinary, cross-functional teams.

 

Responsibilities

  • Establish in vitro and in vivo pharmacology models and assays 
  • Identify CRO and academic partners for in vitro and in vivo pharmacology studies and establish collaborations
  • Lead the development, optimization, and execution of in vitro and in vivo nonclinical pharmacology studies and implement rigorous data analysis techniques to elucidate pharmacodynamic effects. 
  • Manage nonclinical development studies for PepGen's enhanced delivery oligonucleotides to support pre-candidate and early and late development programs in-house and at CROs/academic institutes
  • Partner with Research Project Team leaders, CMC, Toxicology, Bioanalytical, and Biomarkers functions in the design and interpretation of nonclinical pharmacology and efficacy studies as they relate to assessment of PK/PD
  • ​​​​​​​Manage associate scientists and scientific team members
  • Maintain clear technical records and prepare summary presentations and reports of ongoing activities for both internal and external audiences
  • ​​​​​​​Foster a culture of collaboration, innovation, discovery, and cutting-edge research culture focused on scientific excellence, open communication, and continual improvement

Requirements

  • PhD in biomedical science, biochemistry, biology, or related discipline with at least 6+ years of relevant experience in the pharmaceutical industry in preclinical drug discovery and development
  • Experience with in vitro and in vivo preclinical disease models and developing medium- to-high-through put assay formats to support drug development
  • Proficient in techniques, including method development and optimization, critical for molecular and cellular biology experiments e.g., protein and nucleic acid extraction and gene expression analysis by RT-PCR, qPCR and/or digital PCR, western blotting, and ISH
  • Experience with managing and/or conducting studies with CROs
  • Demonstrated experience and expertise in skeletal and/or cardiac muscle biology
  • ​​​​​​​Experience working with cell penetrating peptides, nucleic acids, and/or oligonucleotides conjugates in drug discovery and development is a plus
  • Highly motivated scientist with ability to multitask and prioritize work. Demonstrate ability to thrive in a fast-paced environment and working within timelines
  • Proven ability to work independently, think strategically and be self-motivated
  • Excellent interpersonal skills, ability to work in a matrix environment and develop relationships with key stakeholders
  • Excellent communication and presentation skills to efficiently relay information to project teams, senior management team
  • Experience working with external contract labs is essential
  • Experience with GxP is a plus
  • Experience working in a start-up or small biotech environment is a plus

About PepGen  
PepGen Inc. is a clinical-stage biotechnology company advancing the next-generation of oligonucleotide therapies with the goal of transforming the treatment of severe neuromuscular and neurological diseases. PepGen’s Enhanced Delivery Oligonucleotide, or EDO, platform is founded on over a decade of research and development and leverages cell-penetrating peptides to improve the uptake and activity of conjugated oligonucleotide therapeutics. Using these EDO peptides, we are generating a pipeline of oligonucleotide therapeutic candidates that target the root cause of serious diseases. For more information, visit or follow PepGen on Twitter and LinkedIn. 

 
EEO Statement  
PepGen is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.   

 
Note: This role is 50% in lab

 
Recruitment & Staffing Agencies 
PepGen does not accept unsolicited agency resumes. Currently, we are working exclusively with The Bowdoin Group for all our recruiting needs. Thank you.

Job Tags

Full time, Contract work,

Similar Jobs

Barrick Gold Corporation

Senior Environmental Engineer - Lands Job at Barrick Gold Corporation

 ...Nevada Gold Mines is seeking a highly qualified Senior Environmental Engineer with expertise in closure planning and permitting to join our...  ...in Environmental Engineering, Mine Engineering, Environmental Science, Geology, Hydrology, Ecology, or a related field is required.... 

Amazon.com Services LLC

Logistics Coordinator, OTS Supply Chain - Global Transportation & Logistics Job at Amazon.com Services LLC

 ...data. A day in the life The daily responsibilities of this Amazon logistics coordinator encompass a range of critical tasks to...  ...The coordinator's work is essential for maintaining efficient fulfillment operations, ensuring timely deliveries, and providing upper... 

Burns & McDonnell

Pipeline Engineer - Pipeline & Facilities (Southeast) Job at Burns & McDonnell

 ...Description Our SE Region is seeking Senior Pipeline Engineers to sit in either our Atlanta, GA or Charlotte, NC offices and be responsible...  ...outside personnel Provide short term field support during construction Support business development and marketing initiatives... 

Apex Systems

Pharmacovigilance Scientist Job at Apex Systems

 ...Job Title: Pharmacovigilance Scientist (Contract) Position Summary The Pharmacovigilance Scientist contractor supports safety data analysis for investigational and marketed products in collaboration with the PV Sciences Team and Safety Physician. The role involves signal... 

Geographic Solutions, Inc.

Technical Writer I Job at Geographic Solutions, Inc.

 ...Description Job Summary: The Technical Writer I is responsible for creating and maintaining high-quality documentation for Geographic...  ...Science, or a related field Relevant certifications (e.g., CPTC, UX writing, accessibility) are a plus Special Requirements:...