Job Description
Associate Scientist / Scientist I, Protein Sciences, Analytical/Biophysical Characterizations
October 2025 Department: Technology Work Location: Corporate Headquarters (South San Francisco) Position Summary: TCG Labs-Soleil is seeking a motivated and detail-oriented
Associate Scientist / Scientist I to join our multidisciplinary Protein Sciences group within the Biologics Technology team. This lab-based role will contribute directly to the analytical and biophysical characterization of therapeutic biologics in support of our pre-clinical pipeline. The ideal candidate will bring extensive hands-on experience, demonstrate strong technical execution skills, and generate high-quality, reliable data to drive decision-making in early research programs.
Responsibilities: - Perform analytical and biophysical characterization of proteins, antibodies, and fusion proteins using established methods (e.g., SEC, IEX, HIC, CE-SDS, SDS-PAGE, icIEF, DSF, DSC, and LC-MS).
- Execute experiments independently, record detailed observations, and ensure accuracy and reproducibility of results.
- Analyze and interpret experimental data, apply critical thinking to identify potential issues, and propose next steps.
- Prepare clear experimental protocols, data summaries, and technical reports for internal discussions and presentations.
- Collaborate with team members across disciplines to support program progression.
- Contribute to continuous improvement of workflows and share insights to strengthen group capabilities.
- Maintain instruments, follow laboratory best practices, and ensure experiments are conducted with high standards of quality and safety.
Qualifications: - Bachelor's degree in Biochemistry, Biophysics, Analytical Chemistry, or a related field. Minimum of 10 years of hands-on laboratory experience in protein or antibody characterization in biotech or startup company environment; or
- Master's degree in Biochemistry, Biophysics, Analytical Chemistry, or a related field. Minimum of 8 years of hands-on laboratory experience in protein or antibody characterization in biotech or startup company environment.
- Experience in therapeutic developability studies across monoclonal & multispecific antibodies, fusion proteins preferred.
- Practical knowledge of analytical and biophysical methods, such as SEC, IEX, HIC, CE-SDS, icIEF, DSF, DSC, and LC-MS. Hands-on experience with icIEF and CE-SDS on the Maurice platform, as well as LC-MS for intact and peptide mapping analysis (including data processing with Protein Metrics software), is required.
- A solid understanding of how analytical and biophysical characterizations are applied throughout biologics drug discovery-from hit-to-lead through lead optimization to candidate selection stages.
- Experienced with CMC development processes and contributing to IND filing initiatives is highly desirable.
- Demonstrated ability to generate reliable, high-quality data and maintain meticulous documentation.
- Strong problem-solving and critical-thinking skills with attention to detail.
- Excellent communication skills (written and verbal) and ability to clearly present scientific data.
- Flexible team collaborator, rapidly adapting to new scientific domains and mastering new techniques.
- Proven ability to thrive and achieve results in fast-paced, dynamic, multitasking environments.
Company Overview TCG Labs-Soleil, established in partnership with The Column Group, a science-focused venture capital firm, is pioneering a novel 'venture capital-biotech' model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.
For more details, visit TCGLSoleil.com and follow us on LinkedIn
EEO Statement TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to [click to reveal email address] contact@tcglsoleil.com .
Benefits and Compensation TCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.
The anticipated salary range for fully qualified candidates applying for this role will be $91,000 - $175,000 annually (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity.
Staffing Agencies TCG Labs-Soleil does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn't have a signed agreement with TCG Labs-Soleil. Please do not send agency CVs/resumes through TCG Labs-Soleil website or TCG Labs-Soleil Employees. Inquiries must be sent to [click to reveal email address] contact@tcglsoleil.com with the Subject Heading: Staffing Agency Request.
Job Tags
Full time, Temporary work, Flexible hours,